Heart failure (HF) is a global public health problem with global prevalence of 1–2%(26millions of person). In sub Saharan Africa a systematic review established that HF represent 94% to 42.5% of hospitalisation and 25.6% to 30% hospitalisation in cardiology. Seasonal variation and meteorological variables seem to influence admissions for HF and the evolution of hospitalisation.

To determine whether a seasonal variation exists for HF decompensation in Yaoundé, Cameroon.

Retrospective cross sectional analytical study from the 1^st January 2016 to 31^st December 2018 at Yaoundé Central and General Hospitals. All complete records of patients with chronic HF aged at least 18 years old, and patient hospitalised for decompensated HF were collected. The Cameroonian National Meteorological data base was used during the study period.Statistical tests used were ANOVA and Kruskall-Wallis statistical tests according to the distribution and, Student and Mann Whitney tests to compared the clues between groups of dry and wet months.

We collected 371 eligible patient's files for the study and excluded 4 for lack of data. The global mortality of HF was 6.3% with a lethality of 18%. We found a high frequency of admission during great wet seasons and great dry seasons, without any association. We observed a greater mortality and lethality due to HF decompensation in great wet season and small dry season but with no significant association between the season and the mortality or lethality due to decompensated HF. There was no statistical association between average temperature, total precipitation and admissions for decompensated HF. There was a statistical association between the temperature, mortality and lethality per month of decompensated HF.

Low temperatures and wet season may be associate to the increase of HF decompensation, HF mortality and HF lethality in patient living in Yaoundé, Cameroon.