Comparative Physicochemical Evaluation of Starch Extracted from Pearl millet seeds grown in Sudan as a Pharmaceutical Excipient against Maize and Potato Starch, using Paracetamol as a model drug - 06/01/21
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Highlights |
• | This study aim to compare the physicochemical and disintegrant properties of pearl millet starch with other starches using paracetamol as model drug. |
• | Millet seeds gave a high yield of the starch, which have the same physicochemical properties as maize and potato starch; so can be used as an alternative source for pharmaceutical use. |
• | The yield of the millet starch ranged from 30 to 40%. Moisture content 8.77%, pH 5.7, swelling capacity 1.2, hydration capacity 1.748, moisture uptake 11.8%, amylose 24.6%, with poor flowability and compressibility. |
• | No significant differences in hardness, friability% & disintegration times for formulations containing millet starch to that containing potato and maize starch (P>0.05). |
• | Millet seeds locally cultivated in Sudan, so it is a good alternative with same properties and lower price. |
Summary |
Objectives |
The aim of the current study was to compare the physicochemical and disintegrant properties of pearl millet starch with other starches using paracetamol as model drug.
Methodology |
Determination of percentage yield, Physicochemical, micrometrics characteristics of starch/granules, drug excipients compatibility studies and evaluation of prepared paracetamol tablets were measured using official techniques.
Results |
The yield of the millet starch ranged from 30 to 40%. Moisture content 8.77%, pH 5.7, Swelling capacity 1.2, Hydration capacity 1.748, Moisture uptake 11.8%, Amylose 24.6%, with poor flowability and compressibility. No significant difference in hardness, friability% & disintegration times for formulations containing millet starch to that containing potato and maize starch (P>0.05).
Conclusion |
From the study, Millet seeds locally cultivated in Sudan gave a high yield of starch, has same physicochemical properties as maize and potato starch so can be used as an alternative to those starches.
Le texte complet de cet article est disponible en PDF.Keywords : Pearl millet, Seeds, Starch, Paracetamol, Disintegrants
Plan
Vol 79 - N° 1
P. 28-35 - janvier 2021 Retour au numéro
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