The role of close contacts of COVID-19 patients in the SARS-CoV-2 transmission: an emphasis on the percentage of nonevaluated positivity in Mexico - 23/12/20
, Jorge Ríos-Jasso, MD a, Idalia Garza-Veloz, DSc a, Lucia Reyes-Veyna, MD b, Rosa Maria Cerda-Luna, MD c, Iliana Duque-Jara, MD d, Maribel Galvan-Jimenez, MD e, Leticia A Ramirez-Hernandez, MD f, Andres Morales-Esquivel, MD a, Yolanda Ortiz-Castro, MSc a, Jose R Gutierrez-Camacho, MSc a, José J Valdes-Aguayo, MD a, Jose R Vargas-Rodriguez, MD a
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Graphical Abstract |
Highlights |
• | COVID-19 asymptomatic patients could become an important cause of virus spread. |
• | A high proportion (42%) of close contacts of COVID-19 patients were infected with SARS-CoV-2. |
• | The average of contacts infected with SARS-CoV-2 by index COVID-19 case was 4.3. |
• | The mean of time of SARS-CoV-2 positive test was 18.9 days. |
• | 82.4% of contacts infected with SARS-CoV-2 had less than 2 or had no respiratory symptoms. |
Résumé |
Objectives |
To determine the percentage of positivity of close contacts of coronavirus disease 19 (COVID-19) patients to depict the importance of asymptomatic infections in the patient-to-patient transmission of COVID-19.
Methods |
One hundred subjects were included. Nineteen index COVID-19 cases and 81 traced close contacts were screened for coronavirus 2 of severe acute respiratory syndrome (SARS-CoV-2) using real-time reverse transcription-polymerase chain reaction. Immunoglobulin M and G against SARS-CoV-2 were evaluated by rapid test.
Results |
Thirty-four (42%) contacts in the study were positive for SARS-CoV-2. Twenty-three (67.6%) manifested less than 2 respiratory symptoms, and 5 (14.7%) remained asymptomatic. The average of positive contacts by index COVID-19 case (R0) was 4.3 and the mean of time of positive COVID-19 test at sampling time was 18.9 days. Positive antibody test against SARS-CoV-2 was observed in 16% of the participants.
Conclusion |
The proportion of close contacts of COVID-19 patients infected with SARS-CoV-2 (42%) and with less than 2 or with no respiratory symptoms (82.4%) was high in the study population. A low proportion of COVID-19 patients had a positive test for antibodies against SARS-CoV-2. The screening for SARS-CoV-2 in close contacts of COVID-19 positive patients should be encouraged to avoid spreading the infection and the expansion of the disease.
Le texte complet de cet article est disponible en PDF.Key Words : Antibodies, Asymptomatic contact, COVID-19, SARS-CoV-2
Plan
| This work was funded in part by the Programa de Apoyos para el Fortalecimiento de Capacidades para el Diagnóstico de COVID-19-CONACYT. Grant ID: 314340 (A12 xii. 2020) to Margarita L Martinez-Fierro. |
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| Conflicts of interests: None to report. |
Vol 49 - N° 1
P. 15-20 - janvier 2021 Retour au numéro
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