Together with the rest of the Balkan Peninsula, Greece acted as a refuge for thermophilic amphibians and reptiles during the Quaternary Glaciations. In this work we provide new herpetological data on the latest Early Pleistocene locality of Kaiafas, in western Peloponnese. The site yielded one indeterminate salamandrid urodelan (Salamandridae indet.), one tree frog (Hyla gr. H. arborea), one indeterminate testudinid (Testudinidae indet.), at least two lacertid lizards (Lacertidae indet. A and B), one scincid lizard (Ophiomorus sp.), one anguid lizard (Pseudopus sp.), and one indeterminate “colubrine” snake (“Colubrinae” indet.). This assemblage is indicative of a surrounding environment with water bodies, wooded areas, and possibly loose soils with rocks and stones. In spite of being based on few remains, the study of the amphibians and reptiles from Kaiafas resulted in the identification of the first fossil of Ophiomorus known worldwide. Moreover, the two lacertid taxa displayed very peculiar morphological features which are either previously unknown or rare in that clade.