Prognostic value of postoperative serum carcinoembryonic antigen levels in colorectal cancer patients with chronic kidney disease - 08/12/20
, Li-Kuo Huang b, c, Chin-Yau Chen a, b, Wei-Shu Wang b, d, Shung-Haur Yang a, b, eAbstract |
Background |
Chronic kidney disease (CKD) can increase serum carcinoembryonic antigen (CEA) levels. We thus aimed to evaluate the impact of CKD on CEA prognostic accuracy in colorectal cancer.
Methods |
Altogether, 429 patients who underwent curative resection for stages I–III colorectal adenocarcinoma were grouped according to postoperative CEA levels and history of CKD.
Results |
Three-year disease-free survival (DFS) was higher in patients with normal postoperative CEA (group A, 83.4%) than in those with elevated postoperative CEA (group B, 64.3%) (p < 0.001). CKD patients had higher postoperative CEA levels than non-CKD patients (odds ratio 3.27, 95% confidence interval 1.78–5.99, p < 0.001). In multivariable analysis, postoperative CEA level was an independent prognostic factor for DFS in non-CKD, but not CKD, patients.
Conclusions |
CKD can increase postoperative CEA levels in colorectal cancer patients. Elevated postoperative CEA levels were associated with shorter DFS in non-CKD, but not CKD, patients.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Serum carcinoembryonic antigen (CEA) is a tumor marker in colorectal cancer (CRC). |
• | CRC patients with chronic kidney disease (CKD) have higher CEA levels. |
• | Post-not preoperative CEA level was a better colorectal cancer prognosis factor. |
• | High postoperative CEA level is associated with shorter DFS in non-CKD patients only. |
Keywords : Carcinoembryonic antigen, Chronic kidney disease, Colorectal cancer
Plan
Vol 221 - N° 1
P. 162-167 - janvier 2021 Retour au numéro
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