Hormonal Contraception Effects on Pulmonary Function in Adolescents with Cystic Fibrosis - 04/12/20
, Maude Veilleux-Lemieux, MD 2, Danielle Taddeo, MD 1, Jacques E. Marcotte, MD 3, Ariane Boutin, MD 1, Laurie A. Nguyen, MD 1, Jean-Yves Frappier, MD 1Abstract |
Study Objective |
Estrogens are suspected to have a negative effect on pulmonary function in women with cystic fibrosis (CF). The aim of our study was to investigate, in a CF adolescent population, the effect of hormonal contraception (HC) on lung function by assessing the forced expiratory volume in 1 second (FEV1), the number of exacerbations of pulmonary condition, and antibiotic use.
Design, Setting, Participants, Interventions, and Main Outcome Measures |
We conducted a cohort retrospective chart review of girls from age 13 to 18 years old who were followed in the CF clinic of a university hospital center. Wilcoxon rank sum test with continuity correction, 2-sample t test, conditional test of Poisson rates, and χ2 test were conducted to identify differences in results between adolescents with or without use of HC for the following outcomes: FEV1, use of antibiotics by nebulizer, and hospital admission for exacerbations of pulmonary condition.
Results |
Among 127 adolescents, 64/127 (50.4%) took HC; 12/127 (9%) continuously had been taking HC over 3 years. For girls taking HC for more than 3 years, FEV1 at 18 years old was significantly higher than for girls who had never taken HC (85.17% vs 71.05%; P = .043). However, there was no difference in the number of hospital admissions for exacerbation of pulmonary condition between these 2 groups (P = .057). There was no difference between HC vs non-HC users in the percent of patients taking antibiotics by nebulizer over the 6 years of follow-up.
Conclusion |
Our study suggests that in adolescents with CF, HC has no deleterious effects on the FEV1. Further prospective studies could be done to confirm these results.
Le texte complet de cet article est disponible en PDF.Key Words : Cystic fibrosis, Hormonal contraception, Pulmonary function
Plan
| The authors indicate no conflicts of interest. This research did not receive any specific grant from funding agencies in the public, commercial, ornon-profit sectors. |
Vol 33 - N° 6
P. 681-685 - décembre 2020 Retour au numéro
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