Acromegaly is associated with vertebral deformations but not vertebral fractures: Results of a cross-sectional monocentric study - 28/11/20
, Clarisse Hochman b, 1, Samy Hadjadj a, Benoît Le Goff b, Yves Maugars b, Bertrand Cariou a, Delphine Drui a, 2, Pascale Guillot b, 2Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Acromegalic patients had low prevalence of vertebral fractures. |
• | Study of qualitative abnormalities of the spine in acromegalic patients. |
• | Acromegalic patient had high prevalence of spinal frank deformations. |
Abstract |
Objectives |
Patients with acromegaly appear to be at increased risk of vertebral fractures despite normal bone mineral density. We investigated the prevalence of vertebral fractures in a cohort of acromegalic patients under 80 years of age.
Methods |
Monocentric cross-sectional study performed at Nantes University Hospital from 1988 to 2018. Fifty patients (18 females, 32 males) with a median age of 52.3 years (range: 27–78) were included. Radiological vertebral fractures were evaluated on conventional lumbar and thoracic spine radiographs using Genant's semiquantitative fracture assessment. We studied qualitative abnormalities of the spine using three criteria: osteophytes, disc-space narrowing and wedge-shaped vertebrae. We analysed bone mineral density and endocrine status.
Results |
Three patients (6%) had a vertebral fracture: one grade 1 and two grade 2 according to Genant's assessment, with two osteoporotic and one osteopenic patients. They had no unsubstituted pituitary deficiency. Considering the frank deformations (osteophyte or disc narrowing≥grade 2 or wedge-shaped), the thoracic spine was deformed in 22 patients (44%) and the lumbar spine in 21 patients (42%).
Conclusion |
Acromegalic patients had a low prevalence of vertebral fractures but had a significant amount of vertebral deformations. We speculate that this high prevalence of frank deformations could explain the previously reported high prevalence of vertebral fractures.
Le texte complet de cet article est disponible en PDF.Keywords : Acromegaly, Bone, Spine, Spinal fractures, Growth Hormone, Bone density.
Plan
Vol 87 - N° 6
P. 618-624 - décembre 2020 Retour au numéro
Article précédent
- Sonographic assessment of calcium pyrophosphate deposition disease at wrist. A focus on the dorsal scapho-lunate ligament
- Edoardo Cipolletta, Gianluca Smerilli, Riccardo Mashadi Mirza, Andrea Di Matteo, Marina Carotti, Fausto Salaffi, Walter Grassi, Emilio Filippucci
- Consequences of spinal ankylosis on bone trabecular fragility assessed on CT scans in patients with ankylosing spondylitis. A retrospective study
- Marine Fauny, Caroline Morizot, Edem Allado, Frank Verhoeven, Eliane Albuisson, Marie Semaan, Astrid Pinzano, Isabelle Chary-Valckenaere, Damien Loeuille
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?