Risk of COVID-19 in health-care workers in Denmark: an observational cohort study - 26/11/20
, Henning Bundgaard, ProfDMSc c, Rasmus B Hasselbalch, MD a, b, Jonas H Kristensen, MD a, b, Pernille B Nielsen, MD a, b, Mia Pries-Heje, MD c, Andreas D Knudsen, MD c, d, Casper E Christensen, PhD e, Kamille Fogh, MD a, b, Jakob B Norsk, MD a, b, Ove Andersen, ProfDMSc f, Thea K Fischer, DMSc g, Claus Antonio Juul Jensen, MD h, Margit Larsen, PhD n, Christian Torp-Pedersen, ProfDMSc g, Jørgen Rungby, ProfDMSc i, Sisse B Ditlev, PhD j, Ida Hageman, MD k, Rasmus Møgelvang, PhD c, Christoffer E Hother, MD n, Mikkel Gybel-Brask, PhD n, Erik Sørensen, MD n, Lene Harritshøj, PhD n, Fredrik Folke, ProfPhD l, Curt Sten, MD o, Thomas Benfield, ProfDMSc m, Susanne Dam Nielsen, DMSc d, Henrik Ullum, ProfPhD n
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Summary |
Background |
Health-care workers are thought to be highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVID-19.
Methods |
In this observational cohort study, screening was offered to health-care workers in the Capital Region of Denmark, including medical, nursing, and other students who were associated with hospitals in the region. Screening included point-of-care tests for IgM and IgG antibodies against SARS-CoV-2. Test results and participant characteristics were recorded. Results were compared with findings in blood donors in the Capital Region in the study period.
Findings |
Between April 15 and April 23, 2020, we screened 29 295 health-care workers, of whom 28 792 (98·28%) provided their test results. We identified 1163 (4·04% [95% CI 3·82–4·27]) seropositive health-care workers. Seroprevalence was higher in health-care workers than in blood donors (142 [3·04%] of 4672; risk ratio [RR] 1·33 [95% CI 1·12–1·58]; p<0·001). Seroprevalence was higher in male health-care workers (331 [5·45%] of 6077) than in female health-care workers (832 [3·66%] of 22 715; RR 1·49 [1·31–1·68]; p<0·001). Frontline health-care workers working in hospitals had a significantly higher seroprevalence (779 [4·55%] of 16 356) than health-care workers in other settings (384 [3·29%] of 11 657; RR 1·38 [1·22–1·56]; p<0·001). Health-care workers working on dedicated COVID-19 wards (95 [7·19%] of 1321) had a significantly higher seroprevalence than other frontline health-care workers working in hospitals (696 [4·35%] of 15 983; RR 1·65 [1·34–2·03]; p<0·001). 622 [53·5%] of 1163 seropositive participants reported symptoms attributable to SARS-CoV-2. Loss of taste or smell was the symptom that was most strongly associated with seropositivity (377 [32·39%] of 1164 participants with this symptom were seropositive vs 786 [2·84%] of 27 628 without this symptom; RR 11·38 [10·22–12·68]). The study is registered at ClinicalTrials.gov, NCT04346186.
Interpretation |
The prevalence of health-care workers with antibodies against SARS-CoV-2 was low but higher than in blood donors. The risk of SARS-CoV-2 infection in health-care workers was related to exposure to infected patients. More than half of seropositive health-care workers reported symptoms attributable to COVID-19.
Funding |
Lundbeck Foundation.
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Vol 20 - N° 12
P. 1401-1408 - décembre 2020 Retour au numéro
Article précédent
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