Exploration of plasma interleukin-27 levels in asthma patients and the correlation with lung function - 26/11/20
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Abstract |
Background |
IL-27 attenuates allergic inflammation and improves lung function in mouse models of allergic asthma. However, plasma IL-27 levels of asthma patients and the association with clinical features remain poorly understood.
Methods |
This study examined plasma IL-27 protein expression in untreated asthma patients and controls, analyzed its correlation with Th2 inflammation and lung function, and evaluated the effect of corticosteroids on IL-27 expression.
Results |
Plasma IL-27 levels were lower in untreated asthma patients compared to controls. Plasma IL-27 levels were inversely correlated with sputum IL-5 mRNA expression in Th2Hi group. The Th2HiIL-27Low subgroup suffered from the highest airway hyperresponsiveness (AHR) and the worst pulmonary function. The patients in Th2LowIL-27Low subgroup were less likely to be atopic and had the worst improvement of symptoms after four weeks of standard treatment. In vitro, dexamethasone could decrease the expression of IL-27 in THP-1 cell line. The majority of asthma patients had further decreased IL-27 levels after standard treatment, whereas patients with sustained high levels of IL-27 post-treatment had more blood neutrophils at baseline compared with those without.
Conclusions |
The results indicate that low levels of IL-27 in peripheral blood are closely related to Th2 inflammation and lung function of asthma patients. Low IL-27 levels in combination with high Th2 inflammation identify an asthma phenotype with high AHR and substantial response to corticosteroids. Understanding of this interaction could help to elucidate the inherent inflammation heterogeneity of asthma.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Plasma IL-27 protein level decreased in untreated asthma patients than controls. |
• | IL-27 level was inversely correlated with IL-5 expression in Th2Hi asthma patients. |
• | IL-27 combined Th2 levels can predict lung function and therapeutic responses. |
• | Inhaled corticosteroids may decrease plasma IL-27 levels in asthma patients. |
Keywords : Asthma, IL-27, Airway hyperresponsiveness, Corticosteroids, Lung function
Plan
Vol 175
Article 106208- décembre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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