Therapeutic promises of ginkgolide A: A literature-based review - 18/11/20

Doi : 10.1016/j.biopha.2020.110908

Chandan Sarkar ^a, Cristina Quispe ^b, Sarmin Jamaddar ^a, Rajib Hossain ^a, Pranta Ray ^a, Milon Mondal ^a, Zeinab Abdulwanis Mohamed ^c , Mohammed Sani Jaafaru ^c,^d , Bahare Salehi ^e,⁎ , Muhammad Torequl Islam ^f,^g,⁎ , Ahmad Faizal Abdull Razis ^c,^h,^i,⁎ , Miquel Martorell ^j,^k, Edgar Pastene-Navarrete ^k,^l, Javad Sharifi-Rad ^m,^⁎
^a Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh
^b Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
^c Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
^d Department of Biochemistry, Kaduna State University, Main Campus, PMB 2339, Kaduna, Nigeria
^e Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^f Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
^g Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
^h Laboratory of Food Safety and Food Integrity, Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
ⁱ Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia
^j Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción 4070386, Chile
^k Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción 4070386, Chile
^l Departamento Laboratorio de Síntesis y Biotransformaciones, Departamento de Ciencias Básicas, Universidad del BioBio, Avenida Andrés Bello, 720, Chillán, Chile
^m Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

^⁎Corresponding author at: Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Medical Ethics and Law Research CenterShahid Beheshti University of Medical SciencesTehranIran^⁎⁎Corresponding author at: Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.Laboratory of Theoretical and Computational BiophysicsTon Duc Thang UniversityHo Chi Minh CityViet Nam^⁎⁎⁎Corresponding author at: Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.Laboratory of Molecular BiomedicineInstitute of BioscienceUniversiti Putra MalaysiaUPMSerdangSelangor43400Malaysia^⁎⁎⁎⁎Corresponding author at: Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Phytochemistry Research CenterShahid Beheshti University of Medical SciencesTehranIran

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Abstract

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.

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Keywords : Ginkgolide A, Cancer, Inflammation, Thrombosis, Neurological activity

Plan

Introduction

Materials and methods

Review findings with discussion

Anxiolytic-like effects

Activities against atherosclerosis

Anti-neurotoxic effects

Anti-anesthetics

Anti-inflammatory effects

Hepatoprotective effects

Anti-cancer effects

Antithrombotic effects

Miscellaneous

Conclusion

Funding

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Article 110908- décembre 2020 Retour au numéro

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Therapeutic promises of ginkgolide A: A literature-based review - 18/11/20

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