Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche - 18/11/20
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Abstract |
Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings.
Le texte complet de cet article est disponible en PDF.Abbreviations : BM, HPCs, MSCs, EVs, HSCs, TF, MVs, EXs, Abs, MVBs, AML, TDEXs, NK Cells, VEGF, BM-MDEXs, PGE2, MKs, VCAM-1, BM-DEXs, CLL, AML-DEXs, MDEXs, LDEs, CTL, APC, G-CSF
Keywords : Exosome, Hematopoietic stem cell, Bone marrow niche, Mesenchymal stem cells, Extracellular vehicles
Plan
Vol 132
Article 110854- décembre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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