A review of traditional Chinese medicine on treatment of diabetic retinopathy and involved mechanisms - 18/11/20
, Xianli Meng c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | We summarized and analyzed the prescriptions, herbs and identified compounds of TCM on the treatment of DR from the aspects of anti-inflammation, anti-oxidative stress, anti-angiogenesis and anti-apoptosis. |
• | The detailed mechanisms and involved network pathways of herbs-compounds-targets of TCM in treating DR were reviewed and visualized by Cytoscape software. |
• | We discussed the limitations or deficiencies of TCM on the treatment of DR, and gave the further suggestions. |
Abstract |
As a common ocular complication and microangiopathy of type 2 diabetic mellitus, diabetic retinopathy (DR) can lead to vision loss or even blindness in diabetic patients. At present, the treatment methods of DR mainly include laser and anti-VEGF therapies. Nevertheless, the higher cost and obvious side effects seriously disturb the normal life of DR patients. Promisingly, traditional Chinese medicine (TCM) has been demonstrated to be effective in treating DR by tonifying Qi and nourishing Yin, as well clearing heat and breeding body fluids, thus activating blood and removing blood stasis. Therefore, we screened the literatures on TCM treatment of DR through the web of science, ScienceDirect, PubMed, Google scholar and CNKI online databases. The representative prescriptions, herbs and extracts, and identified compounds for treatment of DR were further summarized and analyzed. Moreover, the detailed mechanisms and involved network pathways of herbs-compounds-targets were visualized by Cytoscape software. Meanwhile, we discussed the existing limitations and deficiencies of TCM on treatment of DR and gave corresponding measures. In conclusion, TCM could significantly ameliorate DR via anti-inflammation, anti-oxidative stress, anti-angiogenesis and anti-apoptosis.
Le texte complet de cet article est disponible en PDF.Abbreviations : A2M, ACC, ADCY-1, AES, AGEs, AMPK, ATF-4, APAF1, BA, Bax, Bcl-2, BDNF, bFGF, Bip, CCL-1, CHOP, ChREBP, COX-2, CRALBP, CRBP, CSPN, CST, CTGF, DC, DR, EEZZR, elF-2α, EPC, ERK1/2, FAS, FBG, FO, FSM, FX, GCL, GFAP, GLAST, GM-CSF, GPR120, GPX, GRb1, GRg1, GRP78/Bip, HAT, HbA-1c, HDAC, HYQRF, HIF-1α, HMGB-1, HO-1, HRECs, HXJD, Iba-1, LBP, ICAM-1, IFN-γ, IGF-1, IL-1α, INL, iNOS, IPL, IRBP, IRE-1α, IRS-1, JAK-2, JNK, LDLC, LJF, LRAT, MCP-1, M-CSF, MEK1/2, MFD, MIG, MIP-1α, MLE, MMP-2/9, MPO, NADPH, NF-κB p65, NLRP-1, 1NMNAT-1, NXT, Nox-4, Nrf-2, OGT, ONL, OPL, p-STAT-3, p-Akt, PARP, PDGF, PECAM, PEDF, p-IKB, p-IKK, PKC-β2, p-MLC, PON-1, pro-EGEG, PSEE, RBG, RCECs, RDH-5, RGC, RMC, RMECs, ROCK-1, ROS, RPECs, SDF-1α, SE, SIRT, SOCS-3, SP-1, SREBP-1, STS, TAK-1, TBARs, TGF-β, TJ, TIMP-1, TLFA, TLR-4, TNFR-1, TNF-α, TNTL, TPP, TrkB, TUDCA, TXNIP, UDCA, VASH, VCAM-1, VEGF, VLDLC, VME, YAP, Zo-1, α-SMA
Keywords : Diabetic retinopathy, Traditional Chinese medicine, Inflammation, Oxidative stress, Angiogenesis, Apoptosis
Plan
Vol 132
Article 110852- décembre 2020 Retour au numéro
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