Current perspectives on the immunopathogenesis of sarcoidosis - 12/11/20
![](/templates/common/images/mail.png)
Abstract |
Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Innate and adaptive immune responses influence progression and determine clinical outcome in sarcoidosis. |
• | Recent studies support an autoimmune component and also the role of microbial organisms as causative agents in sarcoidosis. |
• | Establishment of recent animal and in vitro human models have provided insight in the immunopathogenesis of sarcoidosis. |
Keywords : Sarcoidosis, Innate immune responses, Adaptive immune responses
Plan
Vol 173
Article 106161- novembre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?