Association of sex with clinical outcomes in COVID-19 patients: A retrospective analysis of 1190 cases - 12/11/20

Doi : 10.1016/j.rmed.2020.106159

Jiao Liu ^a,^{^{1
These authors contributed equally to this work.}}, Lidi Zhang ^a,^{^{1
These authors contributed equally to this work.}}, Yizhu Chen ^a,^{^{1
These authors contributed equally to this work.}}, Zhixiong Wu ^b,^{^{1
These authors contributed equally to this work.}}, Xuan Dong ^c,^{^{1
These authors contributed equally to this work.}}, Jean-Louis Teboul ^d,^{^{1
These authors contributed equally to this work.}}, Sheng Zhang ^a, Xiaofei Ye ^e, Yongan Liu ^a, Tao Wang ^a, Hangxiang Du ^a, Wenzhe Li ^a, Dechang Chen ^a,^⁎
^a Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
^b Department of Surgical Intensive Care Unit, Huadong Hospital Affiliated to Fudan University, Shanghai, China
^c Tuberculosis and Respiratory Department, Wuhan Infectious Disease Hospital, Wuhan, China
^d Service de Médecine-Intensive Réanimation, Hôpital Bicêtre, AP-HP, Université Paris-Saclay, Le Kremlin-Bicêtre, France
^e Department of Health Statistics, Second Military Medical University, Shanghai, China

^∗Corresponding author. Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Critical Care MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

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Abstract

Background

The outbreak of COVID-19 caused by SARS-CoV-2 has been a pandemic. The objective of our study was to explore the association between sex and clinical outcomes in patients with COVID-19.

Methods

Detailed clinical data including clinical characteristics, laboratory tests, imaging features and treatments of 1190 cases of adult patients with confirmed COVID-19 were retrospectively analyzed. Associations between sex and clinical outcomes were identified by multivariable Cox regression analysis.

Results

There were 635 (53.4%) male and 555 (46.6%) female patients in this study. Higher rates of acute kidney injury (5.5% vs. 2.9%, p = 0.026), acute cardiac injury (9.1% vs. 4.3%, p = 0.001), and disseminated intravascular coagulation (2.5% vs. 0.7%, P = 0.024) were observed in males. Compared with female patients, male patients with COVID-19 had a higher inhospital mortality rate (15.7% vs. 10.3%, p = 0.005). However, Cox regression analysis showed that sex did not influence inhospital mortality of COVID-19 patients.

Conclusions

Male sex was associated with a worse prognosis of COVID-19, but it seems not to be an independent prognostic factor.

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Keywords : COVID-19, Sex, Organ failure, Mortality

Plan

Demographic and clinical characteristics

Laboratory and radiologic findings and treatments

Clinical outcomes

Multivariable cox regression of inhospital mortality

Discussion

Limitations

Conclusion

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Article 106159- novembre 2020 Retour au numéro

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Association of sex with clinical outcomes in COVID-19 patients: A retrospective analysis of 1190 cases - 12/11/20

Abstract

Background

Methods

Results

Conclusions

Plan

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