Traditional Chinese medicine protects against hypertensive kidney injury in Dahl salt-sensitive rats by targeting transforming growth factor-? signaling pathway - 28/10/20
, Hongxu Liu a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | The role of Bu-Shen-Jiang-Ya decoction on hypertensive renal damage in Dahl salt-sensitive (SS) rats is investigated. |
• | Effectively cutting off the TGF β/SMADs signaling pathway is a significant therapeutic measure for the prevention and treatment of hypertensive renal damage. |
• | Bu-Shen-Jiang-Ya decoction is an optimal therapeutic agent in hypertensive renal damage by inhibiting the TGF β/SMADs signaling pathway. |
Abstract |
This study investigated the therapeutic efficacy of Bu-Shen-Jiang-Ya decoction (BSJYD) on hypertensive renal damage to determine whether it regulates the expression of transforming growth factor-β (TGF-β)/SMADs signaling pathways, thereby relieving renal fibrosis in Dahl salt-sensitive (SS) rats.
Dahl SS rats on a high-sodium diet were prospectively treated with BSJYD (n = 12) or valsartan (n = 12) for 8 weeks. The blood pressure (BP) of these rats was measured and their kidneys were subjected to biochemical analysis, including serum creatinine (Scr) and blood urea nitrogen (BUN); hematoxylin and eosin staining; Masson trichrome staining; real-time polymerase chain reaction; and western blot analysis.
The primary outcome was that BSJYD significantly reduced BP, debased BUN, and Scr and ameliorated renal pathological changes. As underlying therapeutic mechanisms, BSJYD reduces TGFβ1 and Smad2/3 expression and suppresses renal fibrosis, as suggested by the decreased expression of connective tissue growth factor(CTGF). These data suggest that BSJYD acts as an optimal therapeutic agent for hypertensive renal damage by inhibiting the TGF-β/SMADs signaling pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Bu-Shen-Jiang-Ya decoction (BSJYD), Chinese medicine, Hypertensive kidney injury, Dahl salt-sensitive (SS) rats, Transforming growth factor-β (TGF-β) signaling pathway
Plan
Vol 131
Article 110746- novembre 2020 Retour au numéro
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