Medical prevention and treatment of radiation-induced carotid injury - 28/10/20
, Qin Zhao a, b, c, 1 , Jinlong Wei a, b, c , Bin Wang a, b, c , Huanhuan Wang a, b, c , Lingbin Meng d , Ying Xin e, ⁎ , Xin Jiang a, b, c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Radiation-induced carotid injury (RICI) is a potentially lethal clinical complication of head and neck radiotherapy. |
• | The mechanisms of RICI include inflammatory, atherosclerosis, intimal proliferation, media necrosis, and peri-adventitial fibrosis. |
• | CAS is mainly treated with carotid endarterectomy or carotid angioplasty and stent implantation. |
• | BMSCs are advantageous in RICI treatment and reduce carotid inflammation, oxidative stress, and delaying atherosclerosis. |
Abstract |
Radiotherapy has significantly improved the survival of cancer patients but is also associated with several adversities, including radiation-induced carotid injury (RICI). The RICI mechanisms are complex, including vessel inflammatory injury, carotid atherosclerosis, intimal proliferation, media necrosis, and peri-adventitial fibrosis. The main manifestation and adverse consequence of RICI is carotid artery stenosis (CAS), which can lead to stroke and transient ischemic attack. Currently, carotid artery injury is primarily diagnosed via color-coded duplex sonography. Early detection of traumatic changes in the carotid artery depends on measurements of carotid intima-media thickness; serum biomarker testing also shows great potential. CAS is mainly treated with carotid endarterectomy or carotid angioplasty and stent implantation. Notably, bone marrow mesenchymal stem cells are advantageous in RICI treatment and reduce carotid inflammation, oxidative stress, and delaying atherosclerosis. This review summarizes the mechanisms, examination methods, and latest treatments for RICI to provide data for its clinical prevention and treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Carotid artery stenosis, Radiotherapy, Endarterectomy, Oxidative stress, Bone marrow mesenchymal stem cell
Plan
Vol 131
Article 110664- novembre 2020 Retour au numéro
Article précédent
- Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms
- Miao Wang, Hongyan Gao, Weihong Li, Bin Wu
- ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19
- Mengzhen Dong, Jie Zhang, Xuefeng Ma, Jie Tan, Lizhen Chen, Shousheng Liu, Yongning Xin, Likun Zhuang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?