Candesartan could ameliorate the COVID-19 cytokine storm - 28/10/20
, Juan M. Saavedra b, ⁎
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Graphical abstract |
Highlights |
• | Candesartan downregulates expression of many glutamate upregulated genes in cultured neurons. |
• | Glutamate upregulated genes in neurons positively correlate with COVID-19 upregulated genes. |
• | Candesartan gene downregulation negatively correlates with COVID-19 upregulated genes. |
• | Candesartan downregulates genes involved in the COVID-19 cytokine storm. |
Abstract |
Background |
Angiotensin receptor blockers (ARBs) reducing inflammation and protecting lung and brain function, could be of therapeutic efficacy in COVID-19 patients.
Methods |
Using GSEA, we compared our previous transcriptome analysis of neurons injured by glutamate and treated with the ARB Candesartan (GSE67036) with transcriptional signatures from SARS-CoV-2 infected primary human bronchial epithelial cells (NHBE) and lung postmortem (GSE147507), PBMC and BALF samples (CRA002390) from COVID-19 patients.
Results |
Hundreds of genes upregulated in SARS-CoV-2/COVID-19 transcriptomes were similarly upregulated by glutamate and normalized by Candesartan. Gene Ontology analysis revealed expression profiles with greatest significance and enrichment, including proinflammatory cytokine and chemokine activity, the NF-kappa B complex, alterations in innate and adaptive immunity, with many genes participating in the COVID-19 cytokine storm.
Conclusions |
There are similar injury mechanisms in SARS-CoV-2 infection and neuronal injury, equally reduced by ARB treatment. This supports the hypothesis of a therapeutic role for ARBs, ameliorating the COVID-19 cytokine storm.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, SARS-CoV-2, Immunity, Inflammation, NF-κB, Cytokine storm, Interferon, Angiotensin receptor blockers
Plan
Vol 131
Article 110653- novembre 2020 Retour au numéro
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