Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents - 28/10/20
, Zhi-bin Wang c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Entecavir and imipenem alleviated LPS-induced cytokine storm syndrome. |
• | Entecavir and imipenem mitigated LPS-induced acute lung injury. |
• | Entecavir and imipenem inhibited LPS-stimulated TNF-α and IL-10 in hPBMC. |
• | Entecavir and imipenem attenuated LPS-activated NF-κB. |
Abstract |
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate CSS, entecavir and imipenem were identified to reduce TNF-α using a LPS-induced macrophage model from the anti-infective drug library. Entecavir and imipenem efficiently suppressed the release of inflammatory cytokines by partly intervention of NF-κB activity. The acute lung injury was also alleviated and the survival time was prolonged in mice. In addition, entecavir and imipenem inhibited the release of TNF-α and IL-10 in human peripheral blood mononuclear cells (hPBMCs). Collectively, we proposed that entecavir and imipenem might be candidates for the treatment of CSS.
Le texte complet de cet article est disponible en PDF.Abbreviations : ARDS, BALF, CCL-5, COVID-19, CSS, CXCL1, FDA, G-CSF, hPBMC, IC50, IL, IP10, LPS, MCP-1, MERS, MIP-1α, NLRP3, SARS-CoV-2
Chemical compounds studied in this article : Entercavir: PubChem CID 135398508, Imipenem: PubChem CID 104838
Keywords : Cytokine storm, COVID-19, Entecavir, Imipenem, Drug repurposing, Anti-inflammation
Plan
Vol 131
Article 110643- novembre 2020 Retour au numéro
Article précédent
- Effects of conditioned media from human umbilical cord blood-derived mesenchymal stem cells in the skin immune response
- Yoon-Jin Kim, Hee-Jin Ahn, Seung-Hee Lee, Mi-Hye Lee, Kyung-Sun Kang
- Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease : Running title: Propolis against SARS-CoV-2 infection and COVID-19
- Andresa Aparecida Berretta, Marcelo Augusto Duarte Silveira, José Manuel Cóndor Capcha, David De Jong
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?