Potential predictive value of SCN4A mutation status for immune checkpoint inhibitors in melanoma - 28/10/20
, Jian Zhang a, ⁎ , Peng Luo a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 7 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Find predictable biomarker to predict the prognosis of patients receiving ICIs. |
• | SCN4A gene mutations may be one of the indicators to predict the prognosis of ICIs. |
• | We illustrate the mechanism from a macroscopic and microscopic perspective. |
Abstract |
Melanoma refers to a pigmented nevus with malignant changes. The preferred treatment for primary melanoma is surgical excision and postoperative radiotherapy, but the prognosis is poor. Immune checkpoint inhibitors (ICIs) have been remarkably successful in different types of cancers, but not all cancer patients can benefit from it. Therefore, it is essential to find predictable biomarkers and improve the accuracy of treatment. In this study, we used survival analysis, gene panorama analysis, immune cell enrichment analysis, TMB analysis, and GSEA to demonstrate that SCN4A gene mutations may be used as one of the indicators to predict the prognosis of melanoma patients undergoing ICI treatment. The research further indicates that SCN4A gene mutations improve the prognosis of ICI treatment. It is hoped that the effect of SCN4A on immunogenicity and tumor immunity can be demonstrated to further suggest the effect of this gene on the efficacy of ICIs.
Le texte complet de cet article est disponible en PDF.Keywords : SCN4A, TMB, DDR, Melanoma, Immune checkpoint inhibitor
Plan
Vol 131
Article 110633- novembre 2020 Retour au numéro
Article précédent
- The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling
- Samukelisiwe C. Shabalala, Phiwayinkosi V. Dludla, Lawrence Mabasa, Abidemi P. Kappo, Albertus K. Basson, Carmen Pheiffer, Rabia Johnson
- Insight into the proteomic profiling of exosomes secreted by human OM-MSCs reveals a new potential therapy
- Chengfeng Xun, Lite Ge, Feng Tang, Lu Wang, Yi Zhuo, Lang Long, Jiaomei Qi, Li Hu, Da Duan, Ping Chen, Ming Lu
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?