(Re)organisation of the somatosensory system after early brain lesion: A lateralization index fMRI study - 24/10/20
, Eva Chinier b, Pauline Ali b, c, Matthieu Labriffe d, Aram Ter Minassian c, e, Mickael Dinomais b, c
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Highlights |
• | In children with unilateral cerebral palsy, shifting of the sensory function to the contralesioned hemisphere seems uncommon. |
• | Shifting of the sensory function to the contralesioned hemisphere seems ineffective. |
• | Inter-hemispheric plasticity can occur but is unable to compensate for tactile discrimination. |
• | Structural preservation of ipsilesioned primary sensory and secondary sensory cortices is critical in somatosensory processing. |
• | fMRI and lateralization index calculation are well suited to study the reorganization in sensory system. |
Abstract |
Objective |
To evaluate the relationship between neural (re)organization of the somatosensory cortex and impairment of sensory function (2-point discrimination [2PD]) in individuals with unilateral cerebral palsy.
Methods |
We included 21 individuals with unilateral cerebral palsy. 2PD thresholds were evaluated on thumb pads, and activation of the somatosensory cortex was recorded by functional MRI (fMRI) during passive movements of the affected hand. A lateralization index (LI) was calculated for the primary sensory (S1) and secondary sensory (S2) cortices and the correlation between the LI and 2PD thresholds was analysed.
Results |
We found a significant negative correlation between the 2PD thresholds and the S2 LI (r=−0.5, one-tailed P-value=0.01) and a trend towards a negative correlation with the S1 LI (r=−0.4, one-tailed P-value=0.05).
Conclusion |
High levels of activation in the contralesional hemisphere were associated with high levels of sensory impairment in individuals with unilateral cerebral palsy. The interhemispheric (re)organization of the somatosensory system may not effectively compensate for somatosensory impairment.
Le texte complet de cet article est disponible en PDF.Keywords : Cerebral palsy, Sensory function, Plasticity, Functional MRI, Lateralization index, Brain lesion
Plan
Vol 63 - N° 5
P. 416-421 - octobre 2020 Retour au numéro
Article précédent
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