Evaluation of platelet-rich plasma as a treatment for androgenetic alopecia: A randomized controlled trial - 10/10/20
, Anthony Ho, MD a, Kumar Sukhdeo, MD, PhD b, Lu Yin, BA a, Kristen Lo Sicco, MD aAbstract |
Background |
Platelet-rich plasma (PRP) shows promise as an androgenetic alopecia (AGA) treatment.
Objective |
To conduct a randomized placebo-controlled split-scalp study to investigate the effects of PRP on hair regrowth and thickness.
Methods |
Two 7.6-cm × 7.6-cm squares were tattooed on the scalps of 35 study participants with AGA. Areas were randomly assigned to intradermal injection with PRP or saline. Participants received 3 monthly treatment sessions with evaluation 3 months after the final treatment.
Results |
Hair density in the PRP-treated area was significantly increased compared with baseline at all visits. At the final assessment, hair density in PRP-treated areas increased from 151 ± 39.82 hairs/cm2 at baseline to 170.96 ± 37.14 hairs/cm2, a mean increase of approximately 20 hairs/cm2 (P < .05). However, hair density in placebo-treated areas also increased from 151.04 ± 41.99 hairs/cm2 to 166.72 ± 37.13 hairs/cm2 (P < .05). There was no significant difference in hair density change between the 2 groups (P > .05). No serious adverse events were reported.
Limitations |
Possible PRP diffusion due to split-scalp study design as well as microinjections causing microinjury to both sides.
Conclusion |
PRP may have benefit in increasing hair density.
Le texte complet de cet article est disponible en PDF.Key words : androgenetic alopecia, female pattern hair loss, hair, male pattern hair loss, platelet-rich plasma, randomized controlled trial
Abbreviations used : AGA, PRP
Plan
| Funding sources: This study was funded by Regen Lab SA (Le Mont-sur-Lausanne, Switzerland). |
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| Conflicts of interest: Dr Shapiro is a consultant for Aclaris Therapeutics, Incyte, and Replicel Life Sciences and is principal investigator for Regen Lab. Dr Lo Sicco is a coinvestigator for Regen Lab. Authors Ho, Sukhdeo, and Yin have no conflicts of interest to declare. |
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| IRB approval status: The New York University Grossman School of Medicine Institutional Review Board reviewed and approved this study. |
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| Reprints not available from the authors. |
Vol 83 - N° 5
P. 1298-1303 - novembre 2020 Retour au numéro
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