Obesity and asthma - 05/10/20
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Abstract |
Obesity has been well recognized as an important comorbidity in patients with asthma, representing a unique phenotype and endotype. This association indicates a close relationship between metabolic and inflammatory dysregulation. However, the detailed organ-organ, cellular, and molecular interactions are not completely resolved. Because of that, the relationship between obesity and asthma remains unclear. In this article, clinical and epidemiological studies, as well as data from experimental animal work, are being summarized to provide a state of the art update on this important topic. Much more work is needed, particularly mechanistic, to fully understand the interaction between obesity and asthma and to develop novel preventive and therapeutic strategies.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, obesity, metabolism
Abbreviations used : AHR, BMI, FCR, FVC, HDM, HFD, NLRP3, NO, OVA, SNP
Plan
H.R. is supported by the German Lung Centre (DZL). |
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Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 146 - N° 4
P. 685-693 - octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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