Obesity and asthma - 05/10/20

Doi : 10.1016/j.jaci.2020.08.011

Sarah Miethe, MSc ^a,^{∗
Shared first authorship.}, Antonina Karsonova, MD, PhD ^b,^{∗
Shared first authorship.}, Alexander Karaulov, MD, PhD, DMedSc ^b,^{^{‡
Shared last authorship.}}, Harald Renz, MD ^a,^c,^⁎,^{^{‡
Shared last authorship.}}
^a Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
^b Department of Clinical Immunology and Allergology, Laboratory of Immunopathology, Sechenov University, Moscow, Russia
^c German Center for Lung Research (DZL)

^∗Corresponding author: Harald Renz, MD, Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg, Baldingerstrasse, D-35043 Marburg, Germany.Institute of Laboratory Medicine and PathobiochemistryMolecular DiagnosticsPhilipps University of MarburgBaldingerstrasseMarburgD-35043Germany

Abstract

Obesity has been well recognized as an important comorbidity in patients with asthma, representing a unique phenotype and endotype. This association indicates a close relationship between metabolic and inflammatory dysregulation. However, the detailed organ-organ, cellular, and molecular interactions are not completely resolved. Because of that, the relationship between obesity and asthma remains unclear. In this article, clinical and epidemiological studies, as well as data from experimental animal work, are being summarized to provide a state of the art update on this important topic. Much more work is needed, particularly mechanistic, to fully understand the interaction between obesity and asthma and to develop novel preventive and therapeutic strategies.

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Key words : Asthma, obesity, metabolism

Abbreviations used : AHR, BMI, FCR, FVC, HDM, HFD, NLRP3, NO, OVA, SNP

Plan

Obesity and asthma—Clinical and epidemiological evidence

Obesity and asthma: Adults

Obesity and asthma: Sex, ethnic, genetic factors

Obesity and asthma: Children, adolescents

Obesity and asthma: Maternal obesity

Experimental models

Mechanistic studies (human and mouse)

Detailed metabolic assessment: Immune-metabolic interventions

Mechanical effect of obesity on pulmonary function

Weight loss, diet interventions, exercise, and asthma control

Is asthma a risk factor for obesity?

Conclusions

	H.R. is supported by the German Lung Centre (DZL).
	Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.