Recent advances in the synthesis of Quinazoline analogues as Anti-TB agents - 30/09/20
Abstract |
Quinazoline analogues are one of the important nitrogen containing heterocycles that have significant bioactivity as well as found in a plethora of natural products. Tuberculosis is one of the serious universal health threats caused by Mycobacterium tuberculosis (MTB) and primarily affects the lungs. Due to their significant bioactivity and natural occurrences of quinazolines, researchers are trying to synthesize new quinazoline analogues which may have significant potency against tuberculosis. This particular review summarizes recent development of different types of quinazoline bearing analogues as anti-tubercular (anti-TB) agents and their synthesis with structure-activity relationship.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | Mycobacterium tuberculosis is resistant to the most commonly used anti-TB drugs. |
• | Synthesis of new anti-TB agents possessing quinazoline nucleus is very challenging. |
• | First and second line anti-TB drugs fail to give proper recovery during MDR-TB and XDR-TB. |
• | This review article will help researchers discover new anti-TB drugs. |
Keywords : Mycobacterium tuberculosis, Anti-tubercular drugs, Heterocyclic chemistry, Quinazoline analogues, Structure-activity relationship
Plan
Vol 124
Article 101986- septembre 2020 Retour au numéro
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