Elements of whole medical systems (WMSs) are re-emerging in a modern, patient-centered care model that leverages the benefits of evidence-based conventional medical practice with WMSs modalities. Many of these re-emerging modalities had their origins in traditional Chinese medicine, ayurvedic medicine, homeopathy, or naturopathy. To date, research has been conducted predominantly on multimodality treatment of experimental groups, drawing conclusions without a comparative control group or using modalities that are not actually WMSs.