A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis - 22/09/20
, Zhenlie Huang a, 1, ⁎
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Highlights |
• | COVID-19 mortality risk factors were similar to those of SARS and MERS. |
• | Advanced age, hypertension, diabetes, chronic lung disease, increased LDH, CRP, neutrophils and BUN and decreased albumin were positively correlated with COVID-19 mortality. |
• | The laboratory indicators of poor outcomes with the highest degrees of difference were similar among the three coronavirus diseases. |
• | Low lymphocyte subtype counts might be a factor in COVID-19 mortality. |
Summary |
Objective |
Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment.
Methods |
We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI).
Results |
845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56–2.13). Age (OR = 7.86, 95% CI 5.46–11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35–5.90), chronic lung disease (OR = 3.43, 95% CI 1.80–6.52) and hypertension (OR = 3.38, 95% CI 2.45–4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68–57.03), C-reactive protein (OR = 12.11, 95% CI 5.24–27.98), and neutrophils (OR = 17.56, 95% CI 10.67–28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients.
Conclusions |
COVID-19′s mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, SARS, MERS, Mortality, Risk factors, Meta-analysis
Plan
Vol 81 - N° 4
P. e18-e25 - octobre 2020 Retour au numéro
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