The global meningitis genome partnership - 22/09/20
Highlights |
• | Current WGS collections are not representative of the global meningitis picture. |
• | A global overview of WGS data is needed for timely public health intervention. |
• | WHO roadmap to defeat meningitis is ideal stimulus to improve genomic surveillance. |
• | Global Meningitis Genome Partnership will be a major factor in facilitating this. |
Summary |
Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
Le texte complet de cet article est disponible en PDF.Keywords : Whole genome sequencing, Genome partnership, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, Haemophilus influenzae, Bacterial meningitis, Epidemiology
Plan
Vol 81 - N° 4
P. 510-520 - octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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