Carbapenem-alternative strategies for complicated urinary tract infections: A systematic review of randomized controlled trials - 22/09/20
Doi : 10.1016/j.jinf.2020.08.008
T. ten Doesschate a, ⁎ 
, T.W. van der Vaart a, b, J.A.A. Damen a, c, M.J.M. Bonten d, C.H. van Werkhoven a
, T.W. van der Vaart a, b, J.A.A. Damen a, c, M.J.M. Bonten d, C.H. van Werkhoven a a Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Stratenum 6.31, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands
b Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
c Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
d Division of Medical Microbiology, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands
⁎Corresponding author.: Stratenum 6.31, Heidelberglaan 100, 3584 CX Utrecht, Phone: 0031621197660
Highlights |
• | Frequent use of carbapenem increases selection of carbapenem resistant Enterobacterales. |
• | To alleviate this, we reviewed alternative strategies against complicated urinary tract infection. |
• | In sixteen randomized controlled trials, twelve carbapenem-alternatives were investigated. |
• | Four empirical and one pathogen-directed strategies are reasonable alternatives to carbapenem. |
Graphical abstract |
Graphical abstract
Plan
© 2020
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 81 - N° 4
P. 499-509 - octobre 2020 Retour au numéro
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