Ebola virus disease in children in Conakry and Coyah Ebola treatment centers and risk factors associated with death - 22/09/20
Maladie à virus Ébola chez les enfants dans les centres de traitement Ébola de Conakry et de Coyah et facteurs de risque associés au décès
, D.C. Sow a, M.L. Diallo b, D. Kassé b, K. Sylla a, A. Camara c, S.D. Djiro d, M.O.S. Diallo a, E.I. Bah a, I. Bah a, M.P. Diallo bBienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 5 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Study of Ebola virus disease (EVD) in children in two large Ebola treatment centers during the recent epidemic in Guinea, which allowed us to have a representative sample. |
• | Children infected with EVD were under-represented and symptoms were not specific to EVD. |
• | Study findings revealed late consultation of children in Ebola treatment centers with a higher case fatality in young children under 5 years of age as a consequence of an immature immune system. |
• | Hemorrhage is not a common feature of EVD in children; however, it was one of the factors independently associated with death. |
Abstract |
Objective |
To study Ebola virus disease (EVD) in children aged 15 years and below, and to identify risk factors associated with death.
Patients and methods |
Retrospective, multicenter, descriptive, and analytical study of files of children aged 15 years and below in Ebola treatment centers (ETC) of Donka from March 2014 to May 2015. We included all files of children aged 15 years and below hospitalized for EVD in the two ETCs.
Results |
A total of 739 patients hospitalized in both ETCs, 146 children aged 15 years and below (20%) were registered during the study period. The mean age of children was 6.73±4.26 years. Most children were aged above five years (65.8%) and the mean time to consultation was 4.34±3.21 days. The main clinical signs were asthenia (78.8%), fever (75.3%), anorexia (53.4%), headache (45.9%), vomiting (41.8%), abdominal pain (29.5%), and diarrhea (28.8%). The case fatality was 48%, including 54.3% in Coyah and 45% in Conakry. Older age (aOR=0.83, 95% CI [0.76–0.95]), fever (aOR=3.28, 95% CI [1.22–8.87]), diarrhea (aOR=2.98, 95% CI [1.19–4.48]), and hemorrhage (aOR=3.13, 95% CI [1.00–10.38]) were independently associated with death due to EVD.
Conclusion |
EVD remains serious especially in children, with high case fatality. Risk factors independently associated with death were young age, diarrhea, hemorrhage, and fever. Particular attention to these risk factors and vaccination will contribute to improving the prognosis of EVD in children.
Le texte complet de cet article est disponible en PDF.Keywords : Ebola, Children, Ebola treatment center
Plan
Vol 50 - N° 7
P. 562-566 - octobre 2020 Retour au numéro
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