Plasma irisin level associated with hemodynamic parameters and predict clinical outcome in patients with acute pulmonary embolism - 09/09/20

Doi : 10.1016/j.rmed.2020.106072

Na Sun ^a,^b, Youli Fan ^a, Jiaxue Chang ^a, Yiqiang Chen ^c, Xuan Gao ^a, Hongru Sun ^a,^d, Zhuozhong Wang ^a,^b, Xia Gu ^a,^b,^e, Jiangtian Tian ^a,^b, Yingzi Zhao ^a, Bo Yu ^a,^b, Jinwei Tian ^a,^b,^⁎ , Bingxiang Wu ^a,^b,^⁎
^a Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
^b Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China
^c Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
^d Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, China
^e Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, China

^∗Corresponding author. Department of Cardiology, The second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Ministry of Education, NO. 246 Xuefu Road, Nangang District, 150086, Harbin, China.Department of CardiologyThe second Affiliated Hospital of Harbin Medical UniversityThe Key Laboratory of Myocardial IschemiaMinistry of EducationNO. 246 Xuefu RoadNangang DistrictHarbin150086China^∗∗Corresponding author. The second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Ministry of Education, NO. 246 Xuefu Road, Nangang District, 150086, Harbin, China.The second Affiliated Hospital of Harbin Medical UniversityThe Key Laboratory of Myocardial IschemiaMinistry of EducationNO. 246 Xuefu RoadNangang DistrictHarbin150086China

Abstract

Background

The purpose of the present study is to investigate the correlation of plasma irisin level and hemodynamic parameters in patients with acute pulmonary embolism (APE) and to estimate clinical outcome prediction value of plasma irisin level.

Methods

We prospectively recruited 86 adult patients with APE in the present study. All recruited patients conduct measurement of plasma irisin levels using ELISA kits. Baseline clinical characteristics, hemodynamic parameters and prognostic conditions were evaluated according to different plasma irisin levels.

Results

According to median values of irisin levels, APE patients were divided into high irisin group (irisin≥6.9 μg/ml) and low irisin group (irisin<6.9 μg/ml). Plasma NT-proBNP (P = 0.044), mean pulmonary artery pressure (mPAP, P = 0.013), systolic pulmonary artery pressure (sPAP, P = 0.001), mean right ventricular pressure (mRVP, P = 0.021) and systolic right ventricular pressure (sPVP, P = 0.003) were higher in low irisin group compared with high irisin group. Hemodynamic parameters of mPAP, sPAP, mRVP and sRVP were negatively correlated with plasma irisin levels. Kaplan- Meier survival analysis showed that APE patients with lower plasma irisin levels had significantly higher clinical worsening event rate (P = 0.026) and could be the independent predictor of prognosis in multivariate analysis (P = 0.035).

Conclusion

Plasma irisin level was negatively correlated with hemodynamic parameters in patients with APE. Low irisin group patients had significantly higher clinical worsening event rate and could be the independent predictor of clinical outcome in multivariate analysis.

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Highlights

•	Plasma irisin level was negatively correlated with hemodynamic parameters in patients with acute pulmonary embolism.
•	Acute pulmonary embolism patients with relatively lower plasma irisin levels had higher clinical worsening event rates.
•	Low plasma irisin levels could be an independent predictor of adverse clinical outcome in acute pulmonary embolism.

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Keywords : Acute pulmonary embolism, Irisin, Hemodynamic, Clinical outcome

Abbreviations : APE, NT-proBNP, mPAP, sPAP, dPAP, mRVP, sRVP, dRVP, mRAP, sRAP, dRAP