Material selection is one of the most important decisions to be made by clinicians. Proper material selection can affect the long-term function, longevity, and esthetics of restorations. There are a large number of restorative materials available, which has increased the complexity of the decision-making process. Improper material selection can lead to failures in the outcome. This article is designed to provide the practitioner with up-to-date practical information on ceramic restorative materials and techniques in a clear, evidence-based, and unbiased manner. It also provides decision-making guides to help the practitioner determine the best ceramic material for various clinical scenarios.