Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients? - 06/08/20
Doi : 10.1016/j.jinf.2020.06.030
Karl Krupp a 
, Purnima Madhivanan a, b , Carlos M. Perez-Velez b, c, ⁎
, Purnima Madhivanan a, b , Carlos M. Perez-Velez b, c, ⁎ a Department of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, 1295N. Martin Ave.; Drachman Hall A206X; PO Box 245209, Tucson, AZ 85724, USA
b Division of Infectious Diseases, College of Medicine, University of Arizona, Tucson, Arizona, USA
c Pima County Health Department, 3950 South Country Club Road, Suite 100, Tucson, Arizona 84714, USA
⁎Corresponding author at: Pima County Health Department, 3950 South Country Club Road, Suite 100; Tucson Arizona 85714, USA.Pima County Health Department3950 South Country Club Road, Suite 100TucsonArizona85714USA
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Highlights |
• | COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. |
• | Some are being required to continue in isolation until they have negative results. |
• | SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. |
• | Quantitative RT-PCRs and immunoassays are better markers of infectivity period. |
• | Social isolation can have economic, physical, psychological, and social effects. |
Keywords : Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Polymerase chain reaction (PCR), Social Isolation, Infectivity, Virus Shedding, Socioeconomic Impact, Patient Isolation
Abbreviations : COVID-19, ELISA, mL, RNA, RT-PCR, SARS-CoV-2
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© 2020
Publié par Elsevier Masson SAS.
Vol 81 - N° 3
P. 452-482 - septembre 2020 Retour au numéro
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