Comparison of biochemical parameters and chemokine levels in pleural fluid between patients with anergic and non-anergic tuberculous pleural effusion - 30/07/20
, Jaehee Lee b, c Abstract |
Pleural fluid (PF) immune response in anergic tuberculous pleural effusion (TPE) patients is poorly understood. This study aimed to compare PF biochemical parameters and chemokine levels between anergic and non-anergic TPE patients. Chemokine arrays, cytokine measurements, and flow cytometry were performed in 58 patients (TPE [non-anergic (n = 32) and anergic (n = 10)] and malignant pleural effusion (MPE) [n = 16]). PF adenosine deaminase 2 (ADA2) levels were significantly lower in anergic TPE patients than in non-anergic TPE patients (p = 0.048). Among the 40 chemokines tested, PF CCL27 levels were significantly higher in anergic TPE patients than in non-anergic TPE and MPE patients (p < 0.001). The percentage of CD4+CCR10+T cells in PF was higher in anergic TPE patients than in non-anergic TPE and MPE patients (p = 0.001). We reported here that CCL27/CCR10 interactions might contribute to pathophysiology in anergic TPE. PF CCL27 and CD4+CCR10+T cells may help in diagnosing TPE in patients with moderate elevation of PF ADA levels.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Pleural fluid ADA2 is decreased in patients with anergic tuberculous pleural effusion (TPE). |
• | Chemokine CCL27 elevation was observed in the pleural fluid of patients with anergic TPE. |
• | Anergic TPE patients showed increased percentage of CD4+CCR10+T cell in pleural fluid. |
• | Pleural fluid CCL27 may help in diagnosing anergic TPE with moderate ADA elevation. |
Keywords : Tuberculous pleural effusion, Anergy, Adenosine deaminase, CCL27, CCR10
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Vol 123
Article 101940- juillet 2020 Retour au numéro
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