Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis - 26/07/20
Doi : 10.1016/j.jpeds.2020.01.051
Conor McCafferty, BSc (Hons) 1, Xavier Busuttil-Crellin, BSc (Hons) 1, Tengyi Cai, MLabMed 1, Paul Monagle, MBBS, MS 1, 2, 3, Neil A. Goldenberg, MD, PhD 4, 5, Vera Ignjatovic, PhD 1, 2, ⁎ 
1 Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia
2 Department of Paediatrics, The University of Melbourne, Melbourne, Australia
3 Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia
4 Divisions of Hematology, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, St. Petersburg, FL
5 Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL
∗Reprint requests: Vera Ignjatovic, PhD, Haematology Research, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria 3052, AustraliaHaematology ResearchMurdoch Children's Research Institute50 Flemington RoadParkvilleVictoria3052Australia
Abstract |
This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.
Le texte complet de cet article est disponible en PDF.Keywords : hemostasis, pediatrics, plasma, platelet, proteomics
Abbreviations : IPA, PCA, SWATH-MS
Plan
| Publication of this supplement was supported by the Johns Hopkins All Children's Foundation. |
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| Please see the author disclosures at the end of this article. |
© 2020
Publié par Elsevier Masson SAS.
Vol 221 - N° S
P. S29-S36 - juin 2020 Retour au numéro
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