Dynamic profile for the detection of anti-SARS-CoV-2 antibodies using four immunochromatographic assays - 25/07/20
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Abstract |
In order to fight the SARS-CoV-2 pandemic infection, there is a growing need and demand for diagnostic tools that are complementary and different from the RT-PCR currently in use. Multiple serological tests are or will be very soon available but need to be evaluated and validated. We have thus tested 4 immunochromatographic tests for the detection of antibodies to SARS-CoV-2. In addition, we assessed the kinetics of antibody appearance using these assays in 22 patients after they were tested positive by RT-PCR. We observed great heterogeneity in antibody detection post-symptom onset. The median antibody detection time was between 8 and 10 days according to the manufacturers. All the tests showed a sensitivity of 60 to 80% on day 10 and 100% on day 15. In addition, a single cross-reaction was observed with other human coronavirus infections. Thus, immunochromatographic tests for the detection of anti-SARS-CoV-2 antibodies may have their place for the diagnostic panel of COVID-19.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, COVID-19, Antibody, Lateral flow assay
Plan
Vol 81 - N° 2
P. e6-e10 - août 2020 Retour au numéro
Article précédent
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