Urinary HPV DNA testing as a tool for cervical cancer screening in women who are reluctant to have a Pap smear in France - 25/07/20
, Adeline Pivert a, Hélène Le Guillou-Guillemette a, Françoise Lunel-Fabiani a, Pascal Veillon a, Anne-Sophie Le Duc-Banaszuk b, Alexandra Ducancelle aHighlights |
• | A high participation rate as well as a good gynecological follow-up were recovered. |
• | HR-HPV types other than HPV-16/HPV-18 were mostly detected as HPV-53 and HPV-68. |
• | Urine self-sampling is efficient to find high-grade cervical lesions. |
• | Urine samples may be an alternative for women reluctant to have a Pap smear. |
Summary |
Objectives |
In France, cervical cancer screening is based on human papillomavirus (HPV) testing on cervical samples (women aged 30-65) and cytological examination of Pap smears (25-29), but screening coverage is unsatisfactory. The CapU3 study aimed to propose urinary HPV testing on 13,535 women aged 35 to 65 who had not had a Pap smear since 2010.
Methods |
High-risk HPV (HR-HPV) detection was performed using a real-time PCR (Anyplex II HPV 28 Detection, Seegene®). Women with HR-HPV positive results were encouraged to have a cervical smear as soon as possible to detect the presence of cervical lesions.
Results |
The participation rate was 15.4%. Out of the 1,915 analyzed specimens, 1,711 and 190 were negative and positive, respectively, for at least 1 HR-HPV genotype. HR-HPV genotypes other than HPV-16 or HPV-18 were mostly detected as HPV-53 (23.7%) and HPV-68 (14.2%). A satisfactory gynecological follow-up was observed for HPV-positive women (92.1%). 23 abnormal smears were observed and eight high-grade cytological lesions after colposcopy and biopsy were diagnosed.
Conclusions |
As home HPV urinary testing is non-invasive and does not require medical attention, this method may be an alternative for women who are reluctant to have a Pap smear and thus extend screening coverage.
Le texte complet de cet article est disponible en PDF.Keywords : High-risk human papillomavirus, Urine, HPV DNA detection, Cervical cancer screening, Self-sampling
Plan
Vol 81 - N° 2
P. 248-254 - août 2020 Retour au numéro
Article précédent
- Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community
- Kin-On Kwok, Emily Chan, Pui-Hong Chung, Arthur Tang, Wan-In Wei, Chendi Zhu, Steven Riley, Margaret Ip
- Severe air pollution links to higher mortality in COVID-19 patients: The “double-hit” hypothesis.
- Antonio Frontera, Lorenzo Cianfanelli, Konstantinos Vlachos, Giovanni Landoni, George Cremona
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?