Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community - 25/07/20
, Emily Chan d, Pui-Hong Chung a, ⁎ , Arthur Tang e, Wan-In Wei a, Chendi Zhu f, Steven Riley g, Margaret Ip fHighlights |
• | Abundance of ESBL-E in Hong Kong community are causes of concern. |
• | Antibiotic use is associated with ESBL-E carriage. |
• | Presence of MRSA and CPE in the community hints on a change in their epidemiology. |
Abstract |
Objectives |
We conducted a cross-sectional study in Hong Kong community to estimate the carriage prevalence, associated factors and genotypes of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA) and carbapenemase-producing Enterobacteriaceae (CPE).
Methods |
Seemingly healthy subjects were asked to provide nasal, handprint and stool samples from March to April 2017. Isolates were characterized by molecular methods. We used multivariable logistic regression models within a generalized estimating equation framework to identify risk factors for ESBL-E carriage. Characteristics of MRSA/CPE carriage were summarized.
Results |
The prevalence of ESBL-E, MRSA and CPE were 52.8% (104/197), 2.5% (5/197) and 0.5% (1/197) respectively. Most ESBL-E isolates were E. coli (85.6%; 113/132). Most ESBL genes belonged to blaCTX−M-G9 (68.9%) and blaTEM (53.0%) types. Self-reported antibiotic consumption (≥2 courses) in the past six months was associated with ESBL-E carriage (adjusted odds ratio: 4.71–5.47).
Conclusions |
Abundance of ESBL-E in the community are causes of concern, and antibiotic use is associated with its carriage. Presence of MRSA and CPE in community members without clear healthcare exposure hints on a change in their epidemiology. This study establishes a baseline to formulate infection control policies and future studies in combating antimicrobial resistance.
Le texte complet de cet article est disponible en PDF.Keywords : Multidrug resistance, Extended spectrum beta-lactamase, Methicillin-resistant Staphylococcus aureus, Carbapenemase, Community prevalence
Plan
Vol 81 - N° 2
P. 242-247 - août 2020 Retour au numéro
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