Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease - 22/07/20
Doi : 10.1016/j.jpeds.2020.02.025
Aleix Soler-Garcia, MD 1, Anna Gamell, MD, PhD 1, Begoña Santiago, MD, PhD 2, Manuel Monsonís, MD 3, Cristina Calvo, MD, PhD 4, 5, 6, 7, Elvira Cobo, MD 2, Elena Colino, MD 8, María Espiau, MD, PhD 9, Carmelo Guerrero-Laleona, MD 10, Zulema Lobato, MD 11, Andrea Martín-Nalda, MD 9, Beatriz Pérez-Gorricho, MD 12, Tomas M. Perez-Porcuna, MD, PhD 13, 14, Ana Isabel Piqueras, MD 15, Paula Rodríguez-Molino, MD 5, Marta Ruiz, MD 16, Antoni Soriano-Arandes, MD, PhD 9, Teresa Valmanya, MD 17, Marc Tebruegge, DTM&H, MRCPCH, FHEA, MSc, MD, PhD 18, 19, 20, ∗, Antoni Noguera-Julian, MD, PhD 1, 7, 21, 22, ⁎∗ 
on behalf of the
on behalf of the
QFT-Plus Study Group of the Spanish Pediatric TB Research Network (pTBred)†
Elena Colino, David Gómez-Pastrana, Maria Montero, Estrella Peromingo, Matilde Bustillo, Elisenda Moliner, Marina Fenoy, Marta Velásquez, Maria Queralt Soler, Lourdes GARCÍA, Olga Calavia, Neus Rius, Maria Teresa Pascual, Pere Soler-Palacín, Teresa Tórtola, Miguel Lillo, Marta Dapena, Eva María López-Medina, Marta Ruiz, Maria del Mar Santos, Ángel Hernández, Teresa Hernández-Sanpelayo, Alfredo Tagarro, Ana Méndez, María José Mellado, Fernando Baquero-Artigao, Talía Sainz, Miluca García-Hortelano, Javier Álvarez, Enrique Villalobos, María Luz García-García, María Isabel Garrote, José Javier Korta Murua, Nerea Azurmendi Gundín, Laia Sánchez-Torrent, Eneritz Velasco-Arnaiz, Clàudia Fortuny
1 Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Unitat d´Infeccions, Servei de Pediatria, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, Spain
2 Pediatric Infectious Diseases Unit, Gregorio Marañón Hospital, Madrid, Spain
3 Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain
4 Pediatrics Department, Hospital Severo Ochoa, Madrid, Spain
5 Pediatric Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
6 Health Research Institute IdiPAZ, Hospital La Paz, Madrid, Spain
7 Red de Investigación Translacional en Infectología Pediátrica, RITIP, Madrid, Spain
8 Pediatrics Department, Complejo Hospitalario Universitario Insular-Materno Infantil de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
9 Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Barcelona, Spain
10 Unidad de Enfermedades Infecciosas, Servicio de Pediatría, Hospital Universitario Miguel Servet, Zaragoza, Spain
11 Servei de Pediatria, Hospital Sant Joan de Déu, Fundació Althaia, Manresa, Spain
12 Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
13 Atenció Primària, Fundació Assistencial Mútua Terrassa, Terrassa, Spain
14 Unitat de Salut Internacional, Departament de Pediatria, Fundació Recerca Mútua Terrassa, Atenció Primària, Hospital Universitari Mútua de Terrassa, Universitat de Barcelona, Terrassa, Spain
15 Pediatric Infectious Diseases Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain
16 Pediatrics Department, Hospital de Getafe, Madrid, Spain
17 Servei de Pediatria, Hospital Universitari Arnau de Vilanova, Lleida, Spain
18 Department of Pediatric Infectious Diseases & Immunology, Evelina London Childrenś Hospital, Guyś and St. Thomaś NHS Foundation Trust, London, United Kingdom
19 Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom
20 Department of Pediatrics, University of Melbourne, Parkville, Australia
21 Departament de Pediatria, Universitat de Barcelona, Barcelona, Spain
22 CIBER de Epidemiología y Salud Pública, CIBERESP, Madrid, Spain
∗Reprint requests: Antoni Noguera-Julian, MD, PhD, Unitat d´Infeccions, Servei de Pediatria, Hospital Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950 Esplugues, Spain.Unitat d´InfeccionsServei de PediatriaHospital Sant Joan de DéuPasseig Sant Joan de Déu 2Esplugues08950Spain
Abstract |
In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.
Le texte complet de cet article est disponible en PDF.Keywords : diagnosis, interferon-gamma release assay, pediatrics, sensitivity
Abbreviations : BCG, IGRA, LTBI, QFT-GIT, QFT-Plus, pTBred, TST, TB
Plan
| Supported by “Subvencions per a la Intensificació de Facultatius Especialistes” (Departament de Salut de la Generalitat de Catalunya, Programa PERIS 2016-2020) (SLT008/18/00193 [to A.N-J.]). M.T. has received QuantiFERON assays at reduced pricing or free of charge for TB diagnostics projects from the manufacturer (Cellestis/Qiagen) in the past, and has received support for conference attendance from Cepheid. The manufacturers had no influence on the study design, data collection, analysis or interpretation, writing of the manuscript or decision to submit the data for publication. The other authors declare no conflicts of interest. |
© 2020
Elsevier Inc. Tous droits réservés.
Vol 223
P. 212 - août 2020 Retour au numéro
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