Review of talimogene laherparepvec: A first-in-class oncolytic viral treatment of advanced melanoma - 19/06/20
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Abstract |
Talimogene laherparepvec (T-VEC) is an oncolytic virus based on herpes simplex virus type 1 approved for intralesional treatment of advanced melanoma. In this article, we review the clinical literature on T-VEC for advanced melanoma and provide a practical approach to using T-VEC in the dermatologic surgery and oncology clinic. PubMed was used to conduct a systematic literature review of articles describing the structure, basic science, and clinical and therapeutic properties of T-VEC. The national clinical trials database was also searched for T-VEC clinical trials. Phase I to III clinical trials and early real-world experience have shown the efficacy of T-VEC in advanced melanoma as single or combination therapy with tolerable adverse effects. We conclude that with a standardized clinical approach and training, dermatologists can pave the way in using T-VEC and future oncolytic virus therapies in appropriate clinical scenarios.
Le texte complet de cet article est disponible en PDF.Key words : advanced melanoma, cutaneous oncology, oncolytic virus, talimogene laherparepvec (T-VEC)
Abbreviations used : AE, CR, DRR, GM-CSF, HSV, OPTIM, ORR, OV, PFU, PR, T-VEC, VM
Plan
Drs Haitz and Khosravi are cofirst authors. |
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Funding sources: None. |
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Conflicts of interest: None disclosed. |
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IRB approval status: Not applicable. |
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Reprints not available from the authors. |
Vol 83 - N° 1
P. 189-196 - juillet 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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