Treatment of erythrodermic psoriasis with biologics: A systematic review - 19/06/20
, Gabriela Pabón-Cartagena, MD b, Leyre A. Falto-Aizpurua, MD a, Marely Santiago-Vázquez, MD a, Karina J. Cancel-Artau, BS c, Gabriel Arias-Berrios, MD a, Rafael F. Martín-García, MD aAbstract |
Background |
Biologic medications for plaque psoriasis have been used to treat erythrodermic psoriasis (EP). Since the guidelines for management of EP were published, new biologic medications have been approved for the treatment of plaque psoriasis.
Objective |
To analyze the evidence of biologic medications in the treatment of EP based on response and tolerability.
Methods |
A comprehensive search was conducted with the PubMed, Cochrane Library, Embase, and Scopus databases through December 31, 2018. Studies reporting 1 or more cases of EP, defined as >75% body surface area involvement, in patients aged ≥18 years treated with biologics were included. Baseline Psoriasis Area and Severity Index score, score improvement, and adverse events were documented. Adequate response to treatment was defined as Psoriasis Area and Severity Index ≥50.
Results |
Included were 43 articles, yielding a total of 179 patients. Most patients responded at some point during treatment, with a higher level of evidence for infliximab, ustekinumab, ixekizumab, and guselkumab. Infection was the most common adverse event (n = 35).
Limitations |
Data are limited to case reports, case series, and uncontrolled studies.
Conclusion |
Patients with EP treated with biologics demonstrated positive responses and treatment was well-tolerated, with a weak recommendation and limited quality of evidence in favor of infliximab, ustekinumab, ixekizumab, and guselkumab.
Le texte complet de cet article est disponible en PDF.Key words : adalimumab, biologics, erythrodermic psoriasis, etanercept, golimumab, guselkumab, infliximab, ixekizumab, psoriasis, secukinumab, ustekinumab
Abbreviations used : AE, EP, PASI
Plan
| Funding sources: None. |
|
| Conflicts of interest: None disclosed. |
|
| IRB approval status: Not necessary for this systematic review due to all the data being taken from public, anonymous literature. |
|
| Reprints are not available from the authors. |
Vol 83 - N° 1
P. 151-158 - juillet 2020 Retour au numéro
Article précédent
- Long-term safety of nine systemic medications for psoriasis: A cohort study using the Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases (BIOBADADERM) Registry
- Esteban Daudén, Gregorio Carretero, Raquel Rivera, Carlos Ferrándiz, Mar Llamas-Velasco, Pablo de la Cueva, Isabel Belinchón, Francisco José Gómez-García, Enrique Herrera-Acosta, Diana Patricia Ruiz-Genao, Marta Ferrán-Farrés, Mercè Alsina, Ofelia Baniandrés-Rodríguez, José Luis Sánchez-Carazo, Antonio Sahuquillo-Torralba, Lourdes Rodriguez Fernández-Freire, Jaime Vilar-Alejo, Carmen García-Donoso, José Manuel Carrascosa, Enrique Herrera-Ceballos, José Luis López-Estebaranz, Rafael Botella-Estrada, Eva Segovia-Muñoz, Miguel Angel Descalzo, Ignacio García-Doval, the BIOBADADERM Study Group, Esteban Daudén, Mar Llamas-Velasco, Gregorio Carretero, Jaime Vilar-Alejo, Raquel Rivera, Carmen García-Donoso, Carlos Ferrándiz, José Manuel Carrascosa, Ferrán Ballescá, Pablo de la Cueva, Isabel Belinchón, Fran J. Gómez-García, Rafael Jiménez, Enrique Herrera-Ceballos, Enrique Herrera-Acosta, José Luis López-Estebaranz, Diana Patricia Ruiz-Genao, Marta Ferrán Farrés, Mercè Alsina, Ofelia Baniandrés, Lula Nieto, José Luis Sánchez-Carazo, Antonio Sahuquillo-Torralba, Rafael Botella-Estrada, Conrad Pujol Marco, Lourdes Rodríguez Fernández-Freire, Almudena Mateu Puchades, Ángeles Flórez Menéndez, Laura Salgado, Beatriz González Sixto, Noemí Eiris, Ignacio García-Doval, Miguel Ángel Descalzo Gallego, Marina de Vega Martínez
- Buffered lidocaine 1%/epinephrine 1:100,000 with sodium bicarbonate (sodium hydrogen carbonate) in a 3:1 ratio is less painful than a 9:1 ratio: A double-blind, randomized, placebo-controlled, crossover trial
- Alexandra Vent, Christian Surber, Nicole Tracy Graf Johansen, Verena Figueiredo, Georg Schönbächler, Laurence Imhof, Caroline Buset, Jürg Hafner
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?