Ethanol extract of Pycnoporus sanguineus relieves the dextran sulfate sodium-induced experimental colitis by suppressing helper T cell-mediated inflammation via apoptosis induction - 30/05/20
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Highlights |
• | Ethanol extract of Pycnoporus sanguineus (PSE) relieves inflammatory signs of colitis. |
• | PSE enhances tight junction and adherens junction to recover mucosal integrity. |
• | PSE inhibits the helper T cells (Th)-mediated immune response. |
• | PSE suppresses T cells and the Th subset upon stimulation by inducing apoptosis. |
Abstract |
Inflammatory bowel disease (IBD) is a chronic relapsing inflammation involving the gut system, and disequilibrium of T helper (Th) cell paradigm has been recognized as critical pathogenesis. Pycnoporus sanguineus (L.) Murrill is a species of the white-rot basidiomycetes listed as food- and cosmetic-grade microorganisms. In this study, anti-inflammatory activity of the ethanol extract from P. sanguineus (PSE) was investigated in dextran sulfate sodium (DSS)-induced experimental colitis model. PSE recovered the DSS-caused weight loss, reversed the colon shortening, and ameliorated the histopathological lesion in colon, resulting in lower disease activity index (DAI). Levels of serumal lipopolysaccharide (LPS), colonic myeloperoxidase (MPO) in the colitis-suffering mice were declined by PSE treatment. PSE also improved the mucosal integrity by enhancing the expression of tight junction and adherens junction proteins in the colon, including ZO-1, occludin, claudin-1, and E-cadherin. Besides, PSE reduced helper T cells (Th) in the colon, together with an evident decrease of several Th cell-related cytokines. Moreover, it was found that in vitro, PSE suppressed T cells and the Th subset upon Concanavalin A (ConA)-stimulation by inducing apoptosis. In summary, PSE displayed a remission on the colitis-related inflammation, which would possibly rely on the epithelial barrier restoration by suppressing Th cells via apoptosis induction, highlighting a promising potential in the treatment for IBD.
Le texte complet de cet article est disponible en PDF.Abbreviations : AJ, CD, DAI, DSS, IBD, IL, LPS, MPO, PSE, Th, TJ, UC, ZO-1
Keywords : Inflammatory bowel disease, Pycnoporus sanguineus, Helper T cells, Apoptosis
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