Etoricoxib decreases subchondral bone mass and attenuates biomechanical properties at the early stage of osteoarthritis in a mouse model - 30/05/20
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Graphical abstract |
Highlights |
• | Etoricoxib can relieve OA-induced pain and inhibit osteophyte formation in the subchondral bone. |
• | Etoricoxib can change the microstructures and biomechanical properties of subchondral bone. |
• | The effects of Etoricoxib on subchondral bone may be related to its inhibition of PGE2 production. |
Abstract |
Etoricoxib, a selective Cyclooxygenase-2 (COX-2) inhibitor, is commonly used in osteoarthritis (OA) for pain relief, however, little is known about the effects on subchondral bone. In the current study, OA was induced via destabilization of the medial meniscus (DMM) in C57BL/6 mice. Two days after surgery, mice were treated with different concentrations of Etoricoxib. Four weeks after treatment, micro computed tomography (Micro-CT) analysis, histological analysis, atomic force microscopy (AFM) analysis, and scanning electron microscopy (SEM) were performed to evaluate OA progression. We demonstrated that Etoricoxib inhibited osteophyte formation in the subchondral bone. However, it also reduced the bone volume fraction (BV/TV), lowered trabecular thickness (Tb.Th), and more microfractures and pores were observed in the subchondral bone. Moreover, Etoricoxib reduced the elastic modulus of subchondral bone. Exposure to Etoricoxib further increased the empty/total osteocyte ratio of the subchondral bone. Etoricoxib did not show significant improvement in articular cartilage destruction and synovial inflammation in early OA. Together, our observations suggested that although Etoricoxib can relieve OA-induced pain and inhibit osteophyte formation in the subchondral bone, it can also change the microstructures and biomechanical properties of subchondral bone, promote subchondral bone loss, and reduce subchondral bone quality in early OA mice.
Le texte complet de cet article est disponible en PDF.Abbreviations : COX-2, DMM, OA, E5, E10, E20, Micro-CT, HE, AFM, SEM, BV/TV, Tb.Th, OARSI, NSAIDs, COX, PGE2, EP4, MMLT, RT, ROI, EDTA, AVNOA
Keywords : COX-2, Biomechanical properties, Etoricoxib, Microstructures, Osteoarthritis, Subchondral bone
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Vol 127
Article 110144- juillet 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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