Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment - 30/05/20
, Kai Ye c , Jing Lu b , Xinyu Wang d , Shuwen Zhang b , Liu Liu b , Baoyu Yang a , Khaled Nassar b , Xiaoxi Xu a, ⁎ , Xiaoyang Pang b, ⁎ , Jiaping Lv b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 8 |
| Iconographies | 6 |
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Graphical abstract |
Highlights |
• | Oral administration of Lactobacillus plantarum strain YYC-3 substantially inhibited tumour development in APCMin/+ mice. |
• | L. plantarum YYC-3 reduced the production of inflammatory cytokines and infiltrating immune cells. |
• | Oral administration of L. plantarum YYC-3 could preventing alteration of the gut microbiota. |
Abstract |
The gut microbiota plays important roles in chronic inflammation and colon cancer. Lactobacillus is a gut-resident probiotic with benefits to host health. We recently identified Lactobacillus plantarum strain YYC-3 with strong inhibition against two colon cancer cell lines (HT-29 and Caco2). However, the inhibitory effect of YYC-3 against colon cancer in vivo has not been verified. Thus, in the present study, we explored the probiotic function of strain YYC-3 and its cell-free supernatant (YYCS) respectively in the APCMin/+ mouse model of colon cancer during tumour development and growth, and the underlying anti-cancer mechanism. Treatment of both strain YYC-3 and the YYCS prevented the occurrence of colon tumours and mucosal damage in APCMin/+ mice fed a high-fat diet, although YYC-3 had a stronger anti-cancer effect. The mechanism involved modulation of the immune system and downregulated expression of the inflammatory cytokines interleukin (IL)-6, IL-17 F, and IL-22, along with reduced infiltration of inflammatory cells. Moreover, YYC-3 suppressed activation of the NF-κB and Wnt signalling pathways, and restored the altered gut microbiota composition to closely match that of wild-type mice. These results lay a theoretical foundation for application of YYC-3 in colon cancer prevention.
Le texte complet de cet article est disponible en PDF.Keywords : Lactobacillus plantarum YYC-3, Probiotic, Colon cancer, Gut microbiota, Immune system
Plan
Vol 127
Article 110159- juillet 2020 Retour au numéro
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