Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity - 20/05/20
Doi : 10.1016/j.jpeds.2020.01.032
Ryan S. Funk, PharmD, PhD 1, Nasreen J. Talib, MD, MPH 2, Kanecia O. Zimmerman, MD, MPH 3, Leon van Haandel, PhD 4, Mara L. Becker, MD, MSCE 3, ⁎ 
1 Department of Pharmacy Practice, University of Kansas, Kansas City, KS
2 Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO
3 Department of Pediatrics, Duke Clinical Research Institute, Duke University Hospital, Durham, NC
4 AbbVie, North Chicago, IL
∗Reprint requests: Mara L. Becker, MD, MSCE, Associate Professor of Pediatrics, Vice Chair for Faculty, Department of Pediatrics, Division of Pediatric Rheumatology, Duke University School of Medicine, Durham, NC 27710.Vice Chair for FacultyDepartment of PediatricsDivision of Pediatric RheumatologyDuke University School of MedicineDurhamNC27710
Abstract |
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
Le texte complet de cet article est disponible en PDF.Keywords : folates, Down syndrome, pediatrics, precision medicine, toxicity
Abbreviations : 5,10-methenyl-THF, 5-CH3-THF, 5-CH3-THFGlun, MVI
Plan
| Support for this project was provided by a Patton Trust Grant awarded by the Kansas City Area Life Sciences Institute; a Young Investigator Award, awarded by Children's Mercy Hospital, Kansas City, MO; and CTSA grant from National Center for Advancing Translational Sciences, United States (# KL2TR002367) and National Institute for General Medical Sciences, United States (# P20GM1304230) awarded to the University of Kansas for Frontiers: University of Kansas Clinical and Translational Science Institute. The authors declare no conflicts of interest. |
© 2020
Elsevier Inc. Tous droits réservés.
Vol 221
P. 235-239 - juin 2020 Retour au numéro
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