An updated role of astragaloside IV in heart failure - 19/04/20
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Multi-effect of AS- IV in HF.
Abstract |
Heart failure (HF) has become a worldwide public health problem that seriously threatens human’s health. Due to "multi-target" effect, traditional Chinese medicine (TCM) has unique advantages in this field. Chinese herb-derived active components would provide valuable candidate compounds for new drug development. Astragaloside IV(AS-IV) is a main effective ingredient of Astragalus membranaceus, a commonly used Chinese patent medicine for the patients with chronic heart failure(CHF). Our aim is to review the recent progresses of AS-IV in HF, and provide potential evidence for its clinical application. Data showed that AS-IV could protect myocardial ischemia, regulate sarcoplasmic reticulum Ca2+ pump, promote angiogenesis, improve energy metabolism, inhibit cardiac hypertrophy and fibrosis, reduce myocardial cell apoptosis, etc, which are direct or indirect involved in the beneficial effects of AS-IV in rodents or cellular models of HF. AS-IV or its derivatives may act as a potential therapeutic drug in the clinical treatment of HF.
Le texte complet de cet article est disponible en PDF.Abbreviations : TAC, AAC, HUVECs, HMI, LVMI, TDM, HF, ACE, ARBs, MRAs, ARNIs, TCM, AS-IV, CHF, FS, LVSP, LVIDd, LVIDs, AMI, TLR4, NF-κB, Bcl-2, A/R, mPTP, PTEN, PI3K, NO, GSK-3β, SR, SERCA2α, ISO, CaSR, PLC, PKC, PP-1, VEGF, STAT3, JAK, ATP, FFAs, MCPT1, MCAD, PPARα, FAO, LAD, HW/TL, ANP, BNP, β-MHC, SIKE, TBK1, SD, LPS, IL-1β, MCP-1, TNF-α, IL-6, CaN, Nrf2, Ang II, TRPM7, ROS, MAPKs, CT-1, VSMCs, I/R, MMP, mito-NOX4, mito-SOD, mito-CAT, CVB3, MCP-1, NOXs, H/R, MDA, CPK, LDH, GSH-PX, NADPH, eNOS
Keywords : Heart failure, Astragaloside IV, Traditional Chinese medicine, Pharmacological effect
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Article 110012- juin 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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