Current Concepts in the Management of Allergic Fungal Rhinosinusitis - 08/04/20

Doi : 10.1016/j.iac.2019.12.001

Matthew A. Tyler, MD ^a, Amber U. Luong, MD, PhD ^b,^c,^⁎
^a Department of Otolaryngology–Head and Neck Surgery, University of Minnesota Medical School, 516 Delaware Street Southeast, # 8A, Minneapolis, MN 55455, USA
^b Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Texas Sinus Institute, 6431 Fannin Street, MSB 5.036, Houston, TX 77030, USA
^c Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA

^∗Corresponding author. Department of Otorhinolaryngology–Head & Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Texas Sinus Institute, 6431 Fannin Street, MSB 5.036, Houston, TX 77030.Department of Otorhinolaryngology–Head & Neck SurgeryMcGovern Medical School at the University of Texas Health Science CenterTexas Sinus Institute6431 Fannin StreetMSB 5.036HoustonTX77030

Résumé

Allergic fungal rhinosinusitis (AFRS) represents a subtype of chronic rhinosinusitis with nasal polyposis that exhibits a unique, often striking clinical presentation. Since its initial description more than a quarter century ago, a more sophisticated understanding of the pathophysiology of AFRS has been achieved and significant advancements in improving clinical outcomes made. This review focuses on the latest developments involving the pathophysiology and clinical management of this fascinating disease.

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Keywords : Allergic fungal rhinosinusitis, Chronic rhinosinusitis, Nasal polyps, Type 2 inflammation, Allergic sinusitis, Fungal sinusitis, Fungal allergy, Eosinophilic mucin rhinosinusitis