Altered fMRI-derived functional connectivity in patients with high-tension glaucoma - 26/03/20

Doi : 10.1016/j.neurad.2020.03.001

Baojian Wang ^a, Tingqin Yan ^b, Jian Zhou ^c, Yuanzhong Xie ^c, Jianfeng Qiu ^a,^d , Yi Wang ^e,^⁎ , Weizhao Lu ^a,^d,⁎
^a Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China
^b Department of Ophthalmology, Taian City Central Hospital, Taian, China
^c Department of Radiology, Taian City Central Hospital, Taian, China
^d Medical Engineering and Technology Research Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China
^e Department of Ophthalmology, The Second Affiliated hospital of Shandong First Medical University, Taian, China

^⁎Corresponding author at: Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.Department of Radiology, Shandong First Medical University & Shandong Academy of Medical SciencesTaianChina^⁎⁎Co-Corresponding author at: Department of Ophthalmology, The Second Affiliated hospital of Shandong First Medical University, Taian, China.Department of Ophthalmology, The Second Affiliated hospital of Shandong First Medical UniversityTaianChina

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Graphical abstract

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Highlights

•	Functional connectivity was used to assess changes in high-tension glaucoma.
•	Decreased connection was found between the visual cortex and other regions.
•	The results revealed new targets for accurate treatment of glaucoma.

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Abstract

Background

High-tension glaucoma (HTG) is associated with functional changes in the brain, and elevated intraocular pressure (IOP) is one of the major causes.

Purpose

To evaluate the effects of high IOP on the brain in patients with HTG by using resting-state functional magnetic resonance imaging (rs-fMRI).

Materials and methods

Thirty-six patients with HTG and 20 age- and gender-matched healthy controls (HCs) were recruited and underwent IOP examination and rs-fMRI scan. Voxel-wise functional connectivity (FC) values were obtained between the Brodmann Area (BA) 17 (primary visual cortex) and the rest of the brain, two-sample t test was performed between HTG group and HCs. Correlation analysis was performed between FC and clinical information.

Results

Compared with HCs, HTG patients demonstrated decreased FC between BA 17 and the right precuneus gyrus, decreased FC between BA 17 and the right superior frontal gyrus (SFG) (GRF corrected at voxel level P<0.001 and cluster level P<0.05, two-tailed). FC between BA 17 and the right SFG showed significantly negative correlation with right eyes’ IOP and mean IOP.

Conclusion

HTG patients had abnormal FC changes between the visual cortex and multiple functional brain regions related to visual sense, memory consolidation and cognitive processing, which provided image support for the pathophysiology research of HTG, and revealed new targets for the accurate treatment of HTG.

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Keywords : High-tension glaucoma, Resting-state functional magnetic resonance imaging, Functional connectivity