Reverse Sequence Syphilis Screening and Discordant Results in Pregnancy - 20/03/20
Doi : 10.1016/j.jpeds.2019.11.035
Jessica E.P. Williams, MD 1, José A. Bazan, DO 2, 3, Abigail Norris Turner, PhD 2, 4, Stephen F. Thung, MD, MSCI 5, Cory Hanlon, BS 1, 6, Tanisha R. Pettus, MS 3, Pablo J. Sánchez, MD 1, 6, ⁎ 
1 Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH
2 Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus, OH
3 Clinical Health Division, Columbus Public Health, Columbus, OH
4 Division of Epidemiology, The Ohio State University College of Public Health, Columbus, OH
5 Department of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH
6 Divisions of Neonatology and Pediatric Infectious Diseases, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
∗Reprint requests: Pablo J. Sánchez, MD, Professor of Pediatrics, Divisions of Neonatology and Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664.Professor of PediatricsDivisions of Neonatology and Pediatric Infectious DiseasesNationwide Children's HospitalThe Ohio State UniversityCenter for Perinatal ResearchAbigail Wexner Research Institute at Nationwide Children's Hospital700 Children's DriveRB3WB5245ColumbusOH43205-2664
Abstract |
A “reverse sequence syphilis screening” algorithm is widely used for syphilis testing. This retrospective study showed that most (65%) pregnant women with discordant screening results (treponemal multiplex flow immunoassay IgG+/rapid plasma reagin-) had a nonreactive confirmatory Treponema pallidum-particle agglutination assay, likely indicative of a false-positive reaction.
Le texte complet de cet article est disponible en PDF.Keywords : reverse syphilis screening, maternal syphilis, congenital syphilis
Abbreviations : MFI, RPR, TP-PA, VDRL
Plan
| Supported in part by The Ohio State University College of Medicine's Medical Student Research Scholarship funded by the Samuel J. Roessler Memorial Scholarship (to J.W.). The authors declare no conflicts of interest. |
© 2019
Elsevier Inc. Tous droits réservés.
Vol 219
P. 263 - avril 2020 Retour au numéro
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