Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen - 14/03/20
, Xiaohong Chen a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| Iconographies | 9 |
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Graphical abstract |
Highlights |
• | Rhodiola rosea ameliorated severity of EAE mice. |
• | Rhodiola rosea regulated the activities of cytokines in EAE mice. |
• | Rhodiola rosea modulated T cell response in EAE mice. |
• | Rhodiola rosea modulated the relationships of T cell subsets in EAE mice. |
• | Rhodiola rosea regulated JAKs-STATs signalling in EAE mice. |
Abstract |
Adaptogens are stress-response modifiers which have been considered to exert important influences on cytokines activities and immune response. Here, we investigated the effects of Rhodiola rosea (R. rosea), a natural adaptogen on the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We found that R. rosea alleviated the severity of EAE as evaluated by clinical and histopathology scores. R. rosea decreased IL-6, sIL-6R, IFN-γ and IL-17A in both serum and splenocytes supernatants while increased IL-4 in splenocytes supernatants of EAE mice. R. rosea also modulated the T cell response by inhibiting Th1 and Th17 cells, restoring Treg cells, combining with regulated Th17/Th1, Th17/Th2 and Th17/Treg ratios in the spleen, inguinal lymph nodes, brain and spinal cord of EAE mice. Furthermore, R. rosea regulated the expression of JAK1, JAK2, STAT3 and RORγt in the spinal cord of EAE mice. Together, our findings suggested the adaptogenic effects of R. rosea on EAE, which may help to deepen the understanding of potential therapeutic values of traditional Chinese medicines for autoimmune diseases of CNS.
Le texte complet de cet article est disponible en PDF.Abbreviation : MS, CNS, R. rosea, TCM, EAE, JAKs, STAT3, RORγt, NOS, IL-1β, TNF-α, AMPK, mTOR, BDNF, CFA, PTX, IL-6, IL-6R, sIL-6R, IFN-γ, GAPDH, PBS, p.i., HE, LFB, LNs
Keywords : Rhodiola rosea, Adaptogen, Cytokines activities, T cell response, Experimental autoimmune encephalomyelitis
Plan
Vol 125
Article 109960- mai 2020 Retour au numéro
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