Cardiovascular Magnetic Resonance Imaging of Inherited Heart Conditions - 13/03/20

Doi : 10.1016/j.hlc.2019.12.008

Mark Dennis, MBBS, PhD ^a,^b, Martin Ugander, MD, PhD ^c,^d, Rebecca Kozor, MBBS, PhD ^c, Rajesh Puranik, MBBS, PhD ^a,^b,^⁎
^a Sydney Medical School, University of Sydney, Sydney, NSW, Australia
^b Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
^c Kolling Institute, Royal North Shore Hospital, and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia
^d Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden

^∗Corresponding author at: Cardiology Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia. Tel.: 61-2-9515 6111; Fax: 61-2-9519 4938Cardiology DepartmentRoyal Prince Alfred HospitalMissenden Road, CamperdownNSW2050Australia

Abstract

Imaging modalities are central to diagnosis and prognostication of confirmed or suspected inherited cardiomyopathies. The availability and use of cardiovascular magnetic resonance imaging (CMR) to supplement traditional modalities has increased substantially and has several advantages over traditional imaging techniques. CMR is unique in its ability to easily acquire images in any plane. Moreover, advances in CMR sequences have begun to enable characterisation of the myocardium without the need for invasive biopsy and has provided a major step forward in the understanding of inherited heart disease pathology and genotype-phenotype interactions. This review summarises the current role of CMR in inherited cardiomyopathies depending on their genotype and phenotype status, using arrhythmogenic right ventricular dysplasia/cardiomyopathy and hypertrophic cardiomyopathy as prototypical examples.

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Keywords : Cardiac MRI, HCM, ARVC, Mapping, Tissue characterisation